Mitigation of Placebo Response through Subject and Investigator Training

Numerous analgesic treatments examined in recent randomized clinical trials have failed to demonstrate efficacy (including treatments that are reformulations of drugs known to be potent analgesics). One factor in these failures is inflated subject response to placebo.

Dr. Singla will discuss an educational approach to mitigating placebo response in analgesic studies. He will detail systems used in over 30 clinical trials to (1) educate study subjects on the nature of the placebo effect, and (2) train study staff on how best to maintain impartial interactions with subjects at all stages of a study. The goal of this presentation is to give researchers tools to stabilize patient expectations and reduce placebo response.